Diverse Mechanisms of Helicase Loading during DNA Replication Initiation in Bacteria
Helen C. Blaine, Lyle A. Simmons, Christina L. Stallings
Abstract
ntecedent) protein. DciA is not an ATPase, and yet it serves as a helicase operator, providing a function analogous to that of DnaC and DnaI across diverse bacterial species. The recent discovery of DciA and of other alternative mechanisms of helicase loading in bacteria has changed our understanding of DNA replication initiation. In this review, we highlight recent discoveries, detailing what is currently known about the replicative helicase loading process across bacterial species, and we discuss the critical questions that remain to be investigated.
Topics & Concepts
BiologyHelicaseBacillus subtilisControl of chromosome duplicationDNA replicationGeneticsReplication (statistics)Eukaryotic DNA replicationDNA re-replicationBacteriaCell biologyOrigin of replicationPre-replication complexDNAEscherichia coliOrigin recognition complexGeneVirologyRNADNA Repair MechanismsEnzyme Structure and FunctionBacterial Genetics and Biotechnology