Mild ketyl radical generation and coupling with alkynes enabled by Cr catalysis: stereoselective access to <i>E</i>-exocyclic allyl alcohols
Zheng Luo, Xiaoyu Zhang, Zaiyang Li, Meiming Luo, Xiaoming Zeng
Abstract
ZrCl moiety in affording oxazirconiumacycle. This reaction provides a new opportunity for the mild formation of transient ketyl radicals from widely accessible aliphatic aldehydes for coupling with Earth-abundant metal catalysis.
Topics & Concepts
KetylStereoselectivityChemistryCatalysisCoupling (piping)Organic chemistryRadicalMaterials scienceMetallurgyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques