Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site
Ming Sun, Jiaxing Zhao, Qing Mao, Chengda Yan, Bing Zhang, Yuwei Yang, Xiwen Dai, Jun Gao, Fengwei Lin, Yulin Duan, Tingjian Zhang, Shaojie Wang
Topics & Concepts
ChemistryXanthine oxidaseFebuxostatStereochemistryAllopurinolPharmacophoreXanthineDocking (animal)Xanthine oxidase inhibitorPyrimidineHyperuricemiaUric acidBiochemistryEnzymeNursingMedicinePathologyGout, Hyperuricemia, Uric AcidEosinophilic Disorders and SyndromesCase Reports on Hematomas