Investigation of pyrimidine analogues as xanthine oxidase inhibitors to treat of hyperuricemia and gout through combined QSAR techniques, molecular docking and molecular dynamics simulations

Rahman Abdizadeh, Esfandiar Heidarian, Farzin Hadizadeh, Tooba Abdizadeh

2020Journal of the Taiwan Institute of Chemical Engineers30 citationsDOI

Topics & Concepts

ChemistryHyperuricemiaXanthine oxidaseQuantitative structure–activity relationshipPyrimidineStereochemistryGoutMolecular dynamicsDocking (animal)PurineSteric effectsUric acidHydrogen bondComputational chemistryMoleculeEnzymeBiochemistryOrganic chemistryMedicineNursingGout, Hyperuricemia, Uric AcidPharmacological Effects of Natural CompoundsHepatitis C virus research