Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas
Wei Liang, Yingnan Zhang, Liang Zhou, Xiaoqin Lu, Margaret E. Finn, Wei Wang, Hui Shao, Douglas C. Dean, Lijun Zhang, Yongqing Liu
Abstract
littermates through a multidisciplinary approach. We provide evidence that Zeb1 forms a positive regulatory loop with Tgfb to regulate early corneal inflammation by maintenance of immune cell viability and mobility and later wound healing by activation of both Nf-κb and Tgfb-related Stat3 signaling pathways. We believe that ZEB1 is a potential therapeutic target, and inactivation of ZEB1 could be a strategy to treat severe corneal inflammation condition.
Topics & Concepts
InflammationCorneaCorneal inflammationWound healingNeovascularizationAngiogenesisCorneal neovascularizationMedicineImmunologyCancer researchOphthalmologyCorneal Surgery and TreatmentsConnexins and lens biologyAdvanced Glycation End Products research