Peroxisome function relies on organelle-associated mRNA translation
Noa Dahan, Yury S. Bykov, Elizabeth A. Boydston, Amir Fadel, Zohar Gazi, Hodaya Hochberg-Laufer, James S Martenson, Vlad Denic, Yaron Shav‐Tal, Jonathan S. Weissman, Naama Aviram, Einat Zalckvar, Maya Schuldiner
Abstract
. This places peroxisomes alongside chloroplasts, mitochondria, and the endoplasmic reticulum as organelles that use localized translation for ensuring correct insertion of hydrophobic proteins into their membranes. Moreover, the correct targeting of these transcripts to peroxisomes is crucial for peroxisomal and cellular function, emphasizing the importance of localized translation for cellular physiology.
Topics & Concepts
Translation (biology)OrganelleMessenger RNAPeroxisomeFunction (biology)Computational biologyCell biologyBiologyChemistryBiochemistryGeneRNA and protein synthesis mechanismsRNA Research and SplicingRNA modifications and cancer