Dinuclear NHC–gold(<scp>i</scp>)–thiolato and –alkynyl complexes: synthesis, anticancer activity, and catalytic activity in lactonization reactions
Xinyuan Ma, Yuan Zhao, Isabella Caligiuri, Flavio Rizzolio, Nestor Bracho Pozsoni, Kristof Van Hecke, Thomas Scattolin, Steven P. Nolan
Abstract
A series of novel dinuclear NHC-gold-thiolato and -alkynyl complexes bearing aromatic linkers were successfully synthesized by an efficient and simple synthetic route. The catalytic activity of these complexes was tested in a lactonization reaction. The reaction proceeds in high efficiency, in short reaction time and under mild conditions, and is complementary to existing methods. Furthermore, the digold(I)-thiolato derivatives exhibit remarkable cytotoxicity towards several cancer cell lines.
Topics & Concepts
CatalysisChemistryCombinatorial chemistryReaction conditionsCytotoxicityMedicinal chemistryIn vitroStereochemistryOrganic chemistryBiochemistryFerrocene Chemistry and ApplicationsCatalytic Alkyne ReactionsN-Heterocyclic Carbenes in Organic and Inorganic Chemistry