Discovery of an interplay between the gut microbiota and esophageal squamous cell carcinoma in mice.
Man Kit Cheung, Grace Gar‐Lee Yue, Kei Yin Tsui, Adele Joyce Gomes, Hoi Shan Kwan, Philip Wai Yan Chiu, Clara Bik‐San Lau
Abstract
(AP) differentially affected the gut and esophageal microbiome in EC. FMT experiment revealed a reduced anti-metastatic efficacy of AP on liver metastasis in antibiotic-treated xenograft-bearing mice, suggesting a role of the commensal gut microbiota in the anti-metastatic efficacy of the herb. In conclusion, our findings reveal for the first time an interplay between the gut microbiota and EC and provide insights into the treatment strategies for EC.
Topics & Concepts
MicrobiomeGut floraCancer researchBiologyMetastasisImmunologyMedicineCancerInternal medicineBioinformaticsGut microbiota and healthClostridium difficile and Clostridium perfringens researchPancreatic and Hepatic Oncology Research