GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
Vanessa A. N. Kraft, Carla T. Bezjian, Susanne Pfeiffer, Larissa Ringelstetter, Constanze Müller, Fereshteh Zandkarimi, Juliane Merl‐Pham, Xuanwen Bao, Nataša Anastasov, Johanna Kössl, Stefanie Brandner, Jacob D. Daniels, Philippe Schmitt‐Kopplin, Stefanie M. Hauck, Brent R. Stockwell, Kamyar Hadian, Joel Schick
Abstract
, and peroxidation of unusual phospholipids with two polyunsaturated fatty acyl tails. This demonstrates a unique mechanism of ferroptosis protection that is independent of the GPX4/glutathione system.
Topics & Concepts
TetrahydrobiopterinGPX4Programmed cell deathGlutathioneLipid peroxidationCell biologyGTP cyclohydrolase IChemistryBiopterinBiochemistryPhospholipidBiologyOxidative stressNitric oxide synthaseApoptosisEnzymeMembraneGlutathione peroxidaseFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer