Conjugation with gold nanoparticles improves the stability of the KT2 peptide and maintains its anticancer properties
Pornsuda Maraming, Jureerut Daduang, James Chen Yong Kah
Abstract
, 1979. GNPs significantly enhanced the cellular uptake of KT2 peptides after conjugation. Free KT2 peptides pretreated with trypsin were not able to kill MDA-MB-231 cells due to proteolysis, while GNPs-KT2-PEG was still able to exert effective cancer cell killing after trypsin treatment at levels comparable to GNPs-KT2-PEG without enzyme pretreatment. The outcome of this study highlights the utility of conjugated anticancer peptides on nanoparticles to improve peptide stability and retain anticancer ability.
Topics & Concepts
TrypsinPeptideChemistryProteolysisIn vivoPEG ratioConjugated systemIn vitroEnzymeBiochemistryBiologyEconomicsPolymerOrganic chemistryBiotechnologyFinanceAdvanced biosensing and bioanalysis techniquesPeptidase Inhibition and AnalysisAntimicrobial Peptides and Activities