A novel small-molecule fatty acid synthase inhibitor with antitumor activity by cell cycle arrest and cell division inhibition
Hongyan Qu, Kai Shan, Chunlei Tang, Guozhen Cui, Guoling Fu, Yumin Qi, Jing Cui, Jiaqi Li, Rong Wang, Ninghan Feng, Yong Q. Chen
Topics & Concepts
Fatty acid synthaseChemistryCell growthLipogenesisFatty acid synthesisCell cycle checkpointApoptosisIn vivoBiochemistryCell cultureCell cycleDrug discoveryCeruleninEnzymePharmacologyCell biologyLipid metabolismBiologyGeneticsBiotechnologyCancer, Lipids, and MetabolismPeroxisome Proliferator-Activated ReceptorsLipid metabolism and biosynthesis