Mst1 promotes mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes
Yingjie Wang, Qi Yang, Songpo Shen, Linjie Zhang, Yongbo Xiang, Xisheng Weng
Abstract
-treated Mst1-silenced RA-FLSs by inhibiting Sirt1 function or Sirt1 expression, respectively. These findings demonstrate that oxidative stress-related upregulation and activation of Mst1 promotes mitochondrial dysfunction and apoptosis in RA-FLSs by inhibiting the AMPK-Sirt1 signaling pathway. This suggests the Mst1-AMPK-Sirt1 axis is a potential target for RA therapy.
Topics & Concepts
Rheumatoid arthritisOxidative stressApoptosisMedicineCancer researchMitochondrionImmunologyChemistryCell biologyBiologyInternal medicineBiochemistryMicroRNA in disease regulationCircular RNAs in diseasesZiziphus Jujuba Studies and Applications