Synergy of DNA intercalation and catalytic activity of a copper complex towards improved polymerase inhibition and cancer cell cytotoxicity
Adolfo I. B. Romo, Marta S. P. Carepo, Pedro Levín, Otaciro R. Nascimento, Daniel E. Díaz, Joaquín Rodríguez‐López, Ignácio E. León, Lucas F. Bezerra, Luis Lemus, Izaura C.N. Diógenes
Abstract
, which are promising if compared to that of cisplatin, are ascribed to the synergistic effect of ROS generation with the intercalation ability into the DNA minor grooves and blocking DNA replication. This study introduces new principles for synergizing the chemical and structural properties of intercalation compounds for improved drug-DNA interactions targeting cancer.
Topics & Concepts
ChemistryIntercalation (chemistry)DNACytotoxicityNucleaseDNA polymeraseTrigonal bipyramidal molecular geometryReactive oxygen speciesStereochemistryBiochemistryMoleculeInorganic chemistryOrganic chemistryIn vitroMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsSynthesis and Biological Evaluation