NSun2 promotes cell migration through methylating autotaxin mRNA
Xin Xu, Yihua Zhang, Junjie Zhang, Xiaotian Zhang
Abstract
Methylation by NSun2 enhanced ATX mRNA translation. In addition, NSun2-mediated 5-methylcytosine methylation promoted the export of ATX mRNA from nucleus to cytoplasm in an ALYREF-dependent manner. Knockdown of NSun2 suppressed the migration of U87 cells, which was rescued by the addition of LPA. In summary, we identify NSun2-mediated methylation of ATX mRNA as a novel mechanism in the regulation of ATX.
Topics & Concepts
AutotaxinMessenger RNACell biologyChemistryCellBiochemistryBiologyGeneLysophosphatidic acidReceptorRNA modifications and cancerSignaling Pathways in DiseaseGalectins and Cancer Biology