Do metastable polymorphs always grow faster? Measuring and comparing growth kinetics of three polymorphs of tolfenamic acid
Pietro Sacchi, Petros Neoptolemou, Roger J. Davey, Susan M. Reutzel‐Edens, Aurora J. Cruz‐Cabeza
Abstract
. Using approximations for describing the volume of TFA crystals, we show that while crystals of the metastable TFA-II grow the fastest at all solution concentrations, crystals of the metastable TFA-IX become kinetically competitive as the driving force for crystallisation increases. Overall, both metastable forms TFA-II and TFA-IX grow faster than the stable TFA-I.
Topics & Concepts
MetastabilityKineticsChemistryPolymorphism (computer science)CrystallographyMaterials scienceOrganic chemistryBiochemistryPhysicsGenotypeGeneQuantum mechanicsCrystallization and Solubility Studies