PARPi treatment enhances radiotherapy-induced ferroptosis and antitumor immune responses via the cGAS signaling pathway in colorectal cancer
Dongya Shen, Jia Luo, Ling Chen, Wenjuan Ma, Xiao‐Yuan Mao, Yu Zhang, Juyan Zheng, Yang Wang, Jielin Wan, Shiyu Wang, Jing Ouyang, Hanying Yi, Dongbo Liu, Weihua Huang, Wei Zhang, Zhaoqian Liu, Howard L. McLeod, Yijing He
Topics & Concepts
Cancer researchPoly ADP ribose polymeraseProgrammed cell deathImmune systemGene knockdownColorectal cancerBiologyCancer cellCD8Activating transcription factorInonotus obliquusDNA damageCancerImmunologyCell cultureTranscription factorApoptosisDNAPolymeraseBiochemistryGeneGeneticsFerroptosis and cancer prognosisinterferon and immune responsesCancer-related molecular mechanisms research