Rhamnose modified bovine serum albumin as a carrier protein promotes the immune response against sTn antigen
Lin Han, Haofei Hong, Jinfeng Wang, Chen Li, Zhifang Zhou, Zhimeng Wu
Abstract
Rhamnose and sTn antigen were co-conjugated to bovine serum albumin (BSA), a weakly immunogenic carrier protein, for cancer vaccine development. The immune responses against sTn have been significantly augmented with the involvement of Rha-specific antibodies to enhance antigen uptake.
Topics & Concepts
Bovine serum albuminRhamnoseAntigenImmune systemAntibodyChemistrySerum albuminConjugated systemImmunologyAlbuminMolecular biologyBiologyBiochemistryPolysaccharidePolymerOrganic chemistryMonoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins ResearchImmunotherapy and Immune Responses