The role of circulating miRNAs and CA19-9 in pancreatic cancer diagnosis
Nivaldo Faria Vieira, Luciano Neder Serafini, Paulo Cézar Novais, Fermino Sanches Lizarte Neto, Múcio Luiz de Assis Cirino, Rafael Kemp, José Celso Ardengh, Fabiano Pinto Saggioro, Alberto Gaspar, Ajith Kumar Sankarankutty, Jorge Resende Lopes Júnior, Daniela Pretti da Cunha Tirapelli, José Sebastião dos Santos
Abstract
< 0.05) when compared to PCp. The combination of miRNAs-21, -210 tissue expression and serum CA19-9 showed 100% accuracy in the diagnosis of PA, as well as miR-181c expression in the plasma (PApxPCp). The expression of microRNAs in plasma proved to be a promising tool for a noninvasive detection test for PA, as well as further studies will evaluate the utility of microRNAs expression as biomarkers for prognostic and response to therapy in PA.