Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R <sup>+/−</sup> mouse model of ALSP, which can be rescued via CSF1R inhibitors
Miguel A. Arreola, Neelakshi Soni, Joshua Crapser, Lindsay A. Hohsfield, Monica R. P. Elmore, Dina P. Matheos, Marcelo A. Wood, Vivek Swarup, A Mortazavi, Kim N. Green
Abstract
mice at different disease stages with a microglia-modulating dose of the CSF1R inhibitor PLX5622, which prevented microglial dyshomeostasis along with synaptic- and ECM-related deficits. These data highlight microglial dyshomeostasis as a driver of pathogenesis and show that CSF1R inhibition can mitigate these phenotypes.
Topics & Concepts
MicrogliaNeurosciencePerineuronal netChemistryBiophysicsCell biologyBiologyCentral nervous systemImmunologyInflammationNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancerChemokine receptors and signaling