The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation
Pedro Vizán, Arantxa Gutiérrez, Isabel Espejo, Marc García-Montolio, Martin Lange, Ana Carretero, Atefeh Lafzi, Luísa de Andrés-Aguayo, Enrique Blanco, Roshana Thambyrajah, Thomas Graf, Holger Heyn, Anna Bigas, Luciano Di Croce
Abstract
increases HSC identity and quiescence. While proliferation of HSCs is normally triggered by forced mobilization, defects in differentiation impede long-term correct blood production, eventually leading to aberrant hematopoiesis. At molecular level, PHF19 deletion triggers a redistribution of the histone repressive mark H3K27me3, which notably accumulates at blood lineage-specific genes. Our results provide novel insights into how epigenetic mechanisms determine HSC identity, control differentiation, and are key for proper hematopoiesis.