Low-dose aspirin and COX inhibition in human skeletal muscle
William A. Fountain, Masatoshi Naruse, Alex Claiborne, Andrew M. Stroh, Kevin J. Gries, Andrew M. Jones, Kiril Minchev, Bridget Lester, Ulrika Raue, Scott Trappe, Todd A. Trappe
Abstract
This study demonstrated that even low-dose aspirin concentrations can significantly reduce the prostaglandin (PG)E 2 /cyclooxygenase (COX) pathway activity in human skeletal muscle and this effect is not altered during the recovery period following aerobic exercise. These findings are noteworthy since aspirin is one of the most commonly consumed drugs in the world and nonaspirin COX-inhibiting drugs have been shown to regulate skeletal muscle health in sedentary and exercise-training individuals.
Topics & Concepts
AspirinSkeletal muscleCyclooxygenaseMedicineProstaglandinEndocrinologyProstaglandin E2Aerobic exercisePharmacologyInternal medicineChemistryBiochemistryEnzymeInflammatory mediators and NSAID effectsMuscle metabolism and nutritionExercise and Physiological Responses