Systematic Analysis of Mobile Genetic Elements Mediating β-Lactamase Gene Amplification in Noncarbapenemase-Producing Carbapenem-Resistant <i>Enterobacterales</i> Bloodstream Infections
William C. Shropshire, Anna Konovalova, Patrick M. McDaneld, Marc Gohel, Benjamin Strope, Pranoti Sahasrabhojane, Chau Nguyen Tran, David E. Greenberg, J. Kim, Xiaowei Zhan, Samuel L Aitken, Micah M. Bhatti, Tor Savidge, Todd J. Treangen, Blake Hanson, César A. Arias, Samuel A. Shelburne
Abstract
(CNSE) covering a genetically diverse array of isolates, our findings both generate novel insights into how non-CP-CRE overcome carbapenem treatments and provide researchers scaffolds for characterization of their own non-CP-CRE isolates. Improved recognition of mechanisms driving development of non-CP-CRE could assist with design and implementation of future strategies to mitigate the impact of these increasingly recognized AMR pathogens.
Topics & Concepts
CarbapenemMobile genetic elementsMicrobiologyBiologyGeneGeneticsAntibioticsPlasmidAntibiotic Resistance in BacteriaVibrio bacteria research studiesBacterial biofilms and quorum sensing