Empagliflozin treatment rescues abnormally reduced Na<sup>+</sup> currents in ventricular cardiomyocytes from dystrophin-deficient <i>mdx</i> mice
Jakob Sauer, Jessica Marksteiner, Elena Lilliu, Benjamin Hackl, Hannes Todt, Helmut Kubista, Christopher Dostal, Bruno K. Podesser, Attila Kiss, Xaver Koenig, Karlheinz Hilber
Abstract
Dystrophin deficiency in cardiomyocytes leads to abnormally reduced Na + currents. These can be rescued by long-term empagliflozin treatment.
Topics & Concepts
EmpagliflozinDystrophinDuchenne muscular dystrophyInternal medicineMedicineCardiologyEndocrinologyType 2 diabetesDiabetes mellitusMuscle Physiology and DisordersTissue Engineering and Regenerative MedicineAdvanced Sensor and Energy Harvesting Materials