Copper-Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities
Xiaopeng Peng, Zhiqiang Sun, Peihua Kuang, Ling Li, Jingxuan Chen, Jingxuan Chen, Jianjun Chen, Jianjun Chen
Abstract
A novel, simple, and high-yielding approach for the preparation of diarylmethane amide derivatives has been developed by reacting cyclic diaryl iodonium salts with nitriles using CuCl as a catalyst. The procedure is efficient with high atom economy and a wide substrate range. Importantly, selective arylation of nitriles was obtained without affecting the phenyl amino/hydroxyl groups. Furthermore, two of the diarylmethane amides (3k, 3s) displayed excellent neuroprotective and anticancer activities.
Topics & Concepts
ChemistryAmideCatalysisCombinatorial chemistryAtom economyNeuroprotectionSubstrate (aquarium)ArylOrganic chemistryAlkylPharmacologyOceanographyGeologyMedicineCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsSynthesis and Catalytic Reactions