Water-mediated radical C–H tosylation of alkenes with tosyl cyanide
Dongyan Hu, Yang Zhang, Jianwei Li, Kangjiang Liang, Chengfeng Xia
Abstract
A sulfinyl sulfone intermediate, generated in situ by the nucleophilic addition of water to tosyl cyanide, dominated the subsequent tosylation of alkenes via cascade di-radical addition/β-elimination.
Topics & Concepts
TosylCyanideChemistryCombinatorial chemistryOrganic chemistryPolymer chemistrySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods