pH/GSH dual-responsive supramolecular nanomedicine for hypoxia-activated combination therapy
Chang Du, Chenwei Wang, Shu‐Heng Jiang, Xiangqin Zheng, Zelong Li, Yong Yao, Yue Ding, Tingting Chen, Yi Huan
Abstract
, the non-toxic TPZ was activated and converted into the cytotoxic therapeutic agent benzotriazinyl (BTZ) radical under the exacerbated hypoxic microenvironment. Collectively, the PFC/GOD-TPZ provides a promising strategy for effective combination therapy of GOD-mediated starvation therapy, chemodynamic therapy (CDT), and hypoxia-activated chemotherapy (CT).
Topics & Concepts
NanomedicineHypoxia (environmental)Supramolecular chemistryChemistryDual (grammatical number)Combinatorial chemistryNanotechnologyOxygenNanoparticleMaterials scienceOrganic chemistryCrystal structureArtLiteratureNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismSupramolecular Chemistry and Complexes