L-WNK1 is required for BK channel activation in intercalated cells
Evan C. Ray, Rolando Carrisoza‐Gaytan, Mohammad M. Al‐bataineh, Allison L. Marciszyn, Lubika J. Nkashama, Jingxin Chen, Aaliyah Winfrey, Shawn E. Griffiths, Tracey Lam, Daniel Flores, Peng Wu, Wen‐Hui Wang, Chou‐Long Huang, Arohan R. Subramanya, Thomas R. Kleyman, Lisa M. Satlin
Abstract
When mice are placed on a high-K + diet, genetic disruption of the long form of with no lysine kinase 1 (L-WNK1) in intercalated cells reduced relative apical/subapical localization of the large-conductance K + channel, blunted large-conductance K + channel currents in intercalated cells, and increased blood K + concentration. These data confirm an in vivo role of L-WNK1 in intercalated cells in adaptation to a high-K + diet.
Topics & Concepts
BK channelEndocrinologyInternal medicineChemistrySecretionGene isoformBiologyPotassium channelMedicineBiochemistryGeneIon channel regulation and functionElectrolyte and hormonal disordersIon Transport and Channel Regulation