TBAB-Catalyzed 1,6-Conjugate Sulfonylation of para-Quinone Methides: A Highly Efficient Approach to Unsymmetrical gem-Diarylmethyl Sulfones in Water
Zhang-Qin Liu, Peng-Sheng You, Liangdong Zhang, Da-Qing Liu, Sheng-Shu Liu, Xiao-Yu Guan
Abstract
-quinone methides with sulfonyl hydrazines in water has been developed on the basis of the mode involving a tetrabutyl ammonium bromide (TBAB)-promoted sulfa-1,6-conjugated addition pathway. This reaction provides a green and sustainable method to synthesize various unsymmetrical diarylmethyl sulfones, showing good functional group tolerance, scalability, and regioselectivity. Further transformation of the resulting diarylmethyl sulfones provides an efficient route to some functionalized molecules.
Topics & Concepts
Ammonium bromideCatalysisRegioselectivityChemistrySulfonylConjugateBromideQuinoneConjugated systemCombinatorial chemistryDecompositionOrganic chemistryPulmonary surfactantMathematicsMathematical analysisBiochemistryPolymerAlkylSynthesis of Indole DerivativesSulfur-Based Synthesis TechniquesChemical Synthesis and Reactions