Clinical and Molecular Characterizations of Carbapenem-Resistant Klebsiella pneumoniae Causing Bloodstream Infection in a Chinese Hospital
Na Zhang, Lihua Qi, Xiong Liu, Meiling Jin, Yuan Jin, Xiaojing Yang, Jiali Chen, Shiyu Qin, Fangni Liu, Yue Tang, Ruizhong Jia, Xiushan Zhang, Yong Wang, Jinpeng Guo, Jie Liu, Changjun Wang, Yong Chen
Abstract
). Our study suggested that the occurrence of region-specific recombination events manifested by the acquisition of some virulence genes might contribute to serotype switching from ST11-KL47 to ST11-KL64. The accumulation of virulent genes in epidemic resistant strains poses a great challenge for the prevention and treatment of BSI caused by K. pneumoniae in high-risk patients.
Topics & Concepts
Klebsiella pneumoniaeBloodstream infectionMicrobiologyCarbapenemCross infectionKlebsiellaKlebsiella infectionsMedicineBiologyIntensive care medicineAntibioticsGeneGeneticsEscherichia coliAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyBacterial Identification and Susceptibility Testing