A Novel CMY Variant Confers Transferable High-Level Resistance to Ceftazidime-Avibactam in Multidrug-Resistant Escherichiacoli
Junxin Zhou, Weiping Wang, Min Liang, Yu Qian, Shiqi Cai, Tailong Lei, Yan Jiang, Xiaoxing Du, Zhihui Zhou, Yunsong Yu
Abstract
isolates producing AmpC, such as CMY-like cephalosporinase. However, in recent years, CMY variants have been reported to confer ceftazidime-avibactam resistance. We reported a novel CMY variant, CMY-178, that confers high-level ceftazidime-avibactam resistance with potent transferability. Therefore, this resistance gene is a tremendous potential menace to public health and needs attention of clinicians.
Topics & Concepts
Ceftazidime/avibactamAvibactamCeftazidimeMicrobiologyMultiple drug resistanceBiologyDrug resistanceBacteriaGeneticsPseudomonas aeruginosaAntibiotic Resistance in BacteriaPlant Pathogenic Bacteria StudiesAntibiotics Pharmacokinetics and Efficacy