Proteomic analysis of human iPSC-derived sensory neurons implicates cell stress and microtubule dynamics dysfunction in bortezomib-induced peripheral neurotoxicity
Sybil Hrstka, Soneela Ankam, Busranur Agac, Jon P. Klein, Raymond A. Moore, Bhavya Narapureddy, Isabella Schneider, Ronald F. Hrstka, Surendra Dasari, Nathan P. Staff
Topics & Concepts
BortezomibNeuriteMicrotubuleNeurotoxicityBiologyCell biologyCytoskeletonNeuroscienceProteasomeDorsal root ganglionCellSensory systemChemistryBiochemistryImmunologyToxicityMultiple myelomaIn vitroOrganic chemistryUbiquitin and proteasome pathwaysMicrotubule and mitosis dynamicsProtein Degradation and Inhibitors