<i>Ligilactobacillus salivarius</i> CCFM 1266 modulates gut microbiota and GPR109a-mediated immune suppression to attenuate immune checkpoint blockade-induced colitis
Shikai Yan, Leilei Yu, Fengwei Tian, Jianxin Zhao, Wei Chen, Haiqin Chen, Qixiao Zhai
Abstract
L. salivarius CCFM 1266 attenuates ICB-induced colitis via gut microbiota modulation, enhancing Treg, M2 macrophages, and IL-10. Nicotinic acid and GPR109a potentially mediate its effects, preserving antitumor immunity in ICB therapy.
Topics & Concepts
BlockadeColitisImmune systemImmune checkpointImmunologyBiologyLactobacillus salivariusBacteriaImmunotherapyLactobacillusReceptorGeneticsGut microbiota and healthProbiotics and Fermented FoodsClostridium difficile and Clostridium perfringens research