Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy
Yizhu Xu, Huanhuan Wu, Lei Huang, Bingxin Zhai, Xiaofei Li, Shuaiqi Xu, Xingxin Wu, Qihua Zhu, Qiang Xu
Topics & Concepts
Poly ADP ribose polymerasePARP1Wnt signaling pathwaySynthetic lethalityChemistryPARP inhibitorPolymeraseDNA repairHomologous recombinationDNA damageCancer researchMutantDNASignal transductionBiologyBiochemistryGenePARP inhibition in cancer therapyDNA Repair MechanismsPlant Genetic and Mutation Studies