Divergent Trideuteromethylthiolation and Aminotrideuteromethylthiolation of Alkenes with <i>N</i>-Fluorobenzenesulfonimide and CD<sub>3</sub>SSO<sub>3</sub>Na
Wenting Wang, Lin Zhao, Hui Wu, Youqing He, Ge Wu
Abstract
A metal-free oxidative trideuteromethylthiolation of alkenes with CD 3 SSO 3 Na using NFSI as an oxidant has been developed. The aminotrideuteromethylthiolation of a three-component reaction could be easily achieved in the presence of a cobalt catalyst. The divergent trideuteromethylthiolation of alkenes, readily available trideuteromethylthiolation reagent, and versatile synthetic strategy allow for late-stage modification of drug molecules.
Topics & Concepts
ChemistryReagentCombinatorial chemistryCatalysisCobaltMoleculeOrganic chemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods