mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency
Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kensuke Osada, Horacio Cabral, Kazunori Kataoka
Topics & Concepts
ChemistryMessenger RNACytosolEthylene glycolMicelleBiophysicsRNABiochemistryEnzymeBiologyOrganic chemistryAqueous solutionGeneRNA Interference and Gene DeliveryVirus-based gene therapy researchAdvanced biosensing and bioanalysis techniques