Sex differences in vascular aging and impact of GPER deletion
Benard O. Ogola, Caleb Abshire, Bruna Visniauskas, Jasmine X Kiley, Alec C. Horton, Gabrielle L. Clark-Patterson, Isabella Kilanowski‐Doroh, Zaidmara Díaz, Anne N. Bicego, Alexandra B. McNally, Margaret A. Zimmerman, Leanne Groban, Aaron J. Trask, Kristin S. Miller, Sarah H. Lindsey
Abstract
Indices of vascular aging were different in male and female mice. Sex differences in pulse wave velocity, blood pressure, and large artery stiffness were abrogated in middle-aged mice, but the female advantage in resistance artery vasodilator function was maintained. GPER deletion abrogated these sex differences and significantly reduced endothelial function in adult female mice. Additional studies are needed to characterize sex differences in vascular aging to personalize early detection and treatment for vascular diseases.