Complex Flavanones from <i>Cryptocarya metcalfiana</i> and Structural Revision of Oboflavanone A

Abstract

Nine new complex flavanones, cryptometcones A–I (1–9), along with four known analogues, were isolated from Cryptocarya metcalfiana. The structures of 1–9 including their absolute configurations were elucidated by spectroscopic data analysis and electronic circular dichroism (ECD) calculations. In addition, the structure of oboflavanone A was revised, while the absolute configurations of oboflavanone B, cryptoflavanone C, and cryptoflavanone D were determined, according to their spectroscopic data. Compounds 3–5, 8, and 9 exhibited cytotoxicity against the HCT-116 cancer cell line.

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