Intramolecular iron-catalyzed transannulation of furans with <i>O</i>-acetyl oximes: synthesis of functionalized pyrroles
Антон С. Макаров, Alexander A. Fadeev, Maxim G. Uchuskin
Abstract
Intramolecular iron( iii )-catalyzed reaction of furyl-tethered O -acetyl oximes yields substituted pyrroles through electrophilic 5- exo-trig ipso -addition of nitrogen to the furan ring.
Topics & Concepts
ChemistryIntramolecular forceFuranRing (chemistry)CatalysisElectrophileMedicinal chemistryOximeOrganic chemistrySynthesis and Characterization of PyrrolesCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry