Generation of induced pluripotent stem cell line (XDCMHi001-A) from an Ankylosing spondylitis patient with JAK2 mutation
Jintao Hu, Weifan Ren, Weiguo Qiu, Jianlan LV, Cui Zhang, Chao Xu, Weibin Du, Mengrui Wu, Jinfu Wang, Renfu Quan
Abstract
Heredity is the major factor contributing to the susceptibility to ankylosing spondylitis(AS). Janus kinase 2 (JAK2) has been associated with AS. Urine-derived cells from an AS patient with JAK2 mutation were used to generate induced pluripotent stem cells (iPSCs) with five episomal iPSC reprogramming vectors (pCXLE-hOCT3/4-shp53-F, pCXLE-hSK, pCXLE-hUL, pCXLE-EGFP and pCXWB-EBNA1). The iPSCs were pluripotent and will be valuable for research on the role and mechanism of JAK2 in the pathogenesis of AS.
Topics & Concepts
Induced pluripotent stem cellBiologyReprogrammingAnkylosing spondylitisMutationStem cellCancer researchEmbryonic stem cellGeneticsImmunologyCellGeneLiver physiology and pathologyCytokine Signaling Pathways and InteractionsBiomedical Ethics and Regulation