Continuous flow-mode synthesis of (chiral) amines with transaminase: a strategic biocatalytic approach to essential building blocks
Hippolyte Meersseman Arango, Ludivine van den Biggelaar, Patrice Soumillion, Patricia Luis, Tom Leyssens, Francesca Paradisi, Damien P. Debecker
Abstract
Amines, and in particular chiral amines are essential building blocks for the manufacture of active pharmaceutical ingredients. Continuous flow syntheses using immobilized transaminases pave the way to green and intensified production processes.
Topics & Concepts
Continuous flowTransaminaseEnantioselective synthesisChemistryCombinatorial chemistryFlow (mathematics)BiocatalysisOrganic chemistryBiochemical engineeringComputer scienceCatalysisMathematicsEngineeringEnzymeReaction mechanismGeometryEnzyme Catalysis and ImmobilizationInnovative Microfluidic and Catalytic Techniques InnovationMicrobial Metabolic Engineering and Bioproduction