Natural plant-derived nanovesicles for effective psoriasis therapy via dual modulation of IL-17 and NRF2 pathway
Sreeram Peringattu Kalarikkal, Meghana N. Kumar, Sriram Thoppe Rajendran, Cathrine M S Bethi, Jahnavi Ravilla, Narayanan Janakiraman, Gopinath M. Sundaram
Abstract
assay, both shallot and garlic PDNVs displayed percutaneous penetration up to the suprabasal epidermis. Using next generation sequencing and quantitative mRNA profiling in keratinocytes and murine skin, we elucidated a suppressive effect of shallot and garlic PDNVs on IL-17 signaling via modulation of upstream nuclear factor erythroid-2-related factor 2 (NRF2) pathway. Since PDNVs are economical to produce, shallot and garlic PDNVs could be natural and cost-effective topical alternative for psoriasis.
Topics & Concepts
PsoriasisDual (grammatical number)Modulation (music)ChemistryComputational biologyNanotechnologyBiologyMaterials sciencePhysicsImmunologyArtAcousticsLiteraturePsoriasis: Treatment and PathogenesisAutoimmune and Inflammatory Disorders ResearchImmunotherapy and Immune Responses