Imidazole modified Pt(<scp>iv</scp>) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance
Xiaoxu Kang, Yushu Wang, Zhi‐Gang Chen, Yixin Wu, Hao Chen, Xi Yang, Changyuan Yu
Abstract
An imidazole modified Pt(iv) prodrug with a long lipid tail can assemble into multi-stage pH responsive nanoparticles via electrostatic complexation with a negatively charged hydrophilic polymer. This strategy could overcome cisplatin resistance significantly.
Topics & Concepts
ProdrugImidazoleCisplatinChemistryNanoparticleCombinatorial chemistryNuclear chemistryStereochemistryNanotechnologyBiochemistryMaterials scienceChemotherapyMedicineInternal medicineMetal complexes synthesis and propertiesAdvanced biosensing and bioanalysis techniquesDendrimers and Hyperbranched Polymers