Copper-Catalyzed Trifluoromethylthio-arylsulfonylation of Styrene Derivatives via the Insertion of Sulfur Dioxide
Gang Chen, Jie Xu, Baojian Xiong, Hongzhuo Song, Xuemei Zhang, Xuelei Ma, Zhong Lian
Abstract
A copper-catalyzed four-component trifluoromethylthio-arylsulfonylation between styrene derivatives, AgSCF3, aryldiazonium tetrafluoroborates, and ex situ generated sulfur dioxide (from SOgen) is presented. This reaction features mild reaction conditions, good functional group tolerance, a broad substrate scope, good yields, and excellent diastereoselectivity. Preliminary mechanistic studies revealed that a radical process might be involved in this transformation.
Topics & Concepts
ChemistryStyreneSulfur dioxideCatalysisSubstrate (aquarium)Functional groupCopperSulfurScope (computer science)Organic chemistryPolymer chemistryCombinatorial chemistryCopolymerPolymerComputer scienceOceanographyGeologyProgramming languageSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods