Electrocatalytic synthesis of α,α-<i>gem</i>-dihalide ketones from α-mono-halide ketones and unexpected dimer condensation
Bei Zhou, Yu-Juan He, Yun-Feng Tao, Lan-Xiang Liu, Min Hu, Zu-Hui Chang, Hong Lei, Jun Lin, Tong Lin, Guanben Du
Abstract
Starting from α-mono-halide ketone, this paper demonstrates a novel electrocatalytic method of halogenation for α,α- gem -dihalide ketone synthesis and a NaOH-mediated dimer condensation reaction for keto-ester synthesis.
Topics & Concepts
HalideDimerChemistryKetoneCondensationHalogenationOrganic chemistryMedicinal chemistryThermodynamicsPhysicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis