Novel Movable Typing for Personalized Vein‐Chips in Large Scale: Recapitulate Patient‐Specific Virchow's Triad and its Contribution to Cerebral Venous Sinus Thrombosis
Yunduo Charles Zhao, Yingqi Zhang, Zihao Wang, Fengtao Jiang, Kiarash Kyanian, San Seint Seint Aye, Tianbo Hong, Parham Vatankhah, Arian Nasser, Allan Sun, Laura Moldovan, Qian P. Su, Ann‐Na Cho, Yao Wang, Freda Passam, Timothy Ang, Lining Arnold Ju
Abstract
Abstract The Vein‐Chip recapitulates CVST Virchow's triad and enables systematic characterization of venous thrombogenesis with respect to fibrin formation and platelet aggregation. Distinct from the arterial setting, platelets universally adhere across the entire CVS Vein‐Chip independent of stenotic geometry and flow disturbance. Intriguingly, fibrin propagates along with the flow direction, but exclusively deposits to the inner vessel wall. Upon inflammatory endothelial injury, fibrin deposition mirrors to the outer vessel wall, but still not in the lumen. Together, the Vein‐Chip promises future applications for personalized thrombotic assessment and monitoring.