Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment
Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Elam Cutts, Lori L. McMahon, Jennifer S. Pollock, David M. Pollock, Shannon M. Bailey, Karen L. Gamble
Abstract
access to an HFD for 20 weeks increased body weight and fat mass, increased daytime meal consumption, reduced hippocampal long-term potentiation (LTP), and eliminated day/night differences in spatial working memory. Importantly, two weeks of time-restricted feeding (TRF) at the end of the chronic HFD protocol rescued spatial working memory and restored LTP magnitude, even though there was no change in body composition and total daily caloric intake. These findings suggest that short-term TRF is an effective mechanism for rescuing HFD-induced impaired cognition and hippocampal function.
Topics & Concepts
Hippocampal formationLong-term potentiationHippocampusEndocrinologyMealInternal medicineMemory impairmentNeurosciencePeriod (music)BiologyMedicineCognitionAcousticsPhysicsReceptorDietary Effects on HealthCircadian rhythm and melatoninDiet and metabolism studies