Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles
Yutong Guo, Hohyun Lee, Zhou Fang, Anastasia Velalopoulou, Jinhwan Kim, Midhun Ben Thomas, Jingbo Liu, Ryan G. Abramowitz, YongTae Kim, Ahmet F. Coskun, Daniel Pomeranz Krummel, Soma Sengupta, Tobey J. MacDonald, Costas Arvanitis
Abstract
-activated medulloblastoma model. Moreover, our analysis reveals that MB-FUS and nanoparticle properties can be optimized to maximize delivery in the brain tumor microenvironment, thereby serving as a platform for developing next-generation tunable delivery systems for RNA-based therapy in brain tumors.
Topics & Concepts
NanoparticleUltrasoundCellApoptosisOncogeneCancer researchSmall interfering RNARNANanotechnologyChemistryMedicineMaterials scienceCell cycleBiochemistryRadiologyGeneUltrasound and Hyperthermia ApplicationsRNA Interference and Gene DeliveryExtracellular vesicles in disease