Brain differences in the prefrontal cortex, amygdala, and hippocampus in youth with congenital adrenal hyperplasia
Herting MM, Anisa Azad, Kim R, J. Michael Tyszka, ME Geffner, Kim Ms
Abstract
Classical congenital adrenal hyperplasia (CAH) is characterized by impaired glucocorticoid, and often also mineralocorticoid, secretion and increased adrenal androgen production (1). Given the widespread expression of androgen and glucocorticoid receptors throughout the brain (2, 3), there has been a growing interest in understanding how hormonal imbalances related to CAH may impact distinct subregions of the developing brain (4).
Topics & Concepts
Congenital adrenal hyperplasiaAmygdalaMineralocorticoidGlucocorticoidHippocampusEndocrinologyAndrogenInternal medicinePrefrontal cortexGlucocorticoid receptorAdrenal cortexNeuroscienceHormoneMedicinePsychologyCognitionSexual Differentiation and DisordersAdrenal Hormones and DisordersHormonal and reproductive studies