Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review
Jinfan Tian, Mohammad Sharif Popal, Rongchong Huang, Min Zhang, Xin Zhao, Mingduo Zhang, Xiantao Song
Abstract
Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.
Topics & Concepts
CaveolaeCrosstalkCaveolin 1AutophagySignal transductionCaveolinOxidative stressCell biologyBiogenesisNitric oxideHomeostasisMedicineFunction (biology)NeuroscienceBioinformaticsBiologyBiochemistryInternal medicineApoptosisGeneOpticsPhysicsCaveolin-1 and cellular processesLipid metabolism and disordersIon Transport and Channel Regulation