Longitudinal association between hippocampus atrophy and episodic‐memory decline in non‐demented <i>APOE</i> ε4 carriers
Tetiana Gorbach, Sara Pudas, David Bartrés‐Faz, Andreas M. Brandmaier, Sandra Düzel, Richard N. Henson, Ane‐Victoria Idland, Ulman Lindenberger, Didac Macià Bros, Athanasia M. Mowinckel, Cristina Solé‐Padullés, Øystein Sørensen, Kristine B. Walhovd, Leiv Otto Watne, René Westerhausen, Anders M. Fjell, Lars Nyberg
Abstract
INTRODUCTION: ) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus atrophy and episodic-memory decline in non-demented individuals remains unclear. METHODS: consortium. RESULTS: = .013]. A similar trend toward a stronger change-change relation for carriers was seen in a subsample with more than two assessments. DISCUSSION: These findings provide evidence for a difference in hippocampus-memory association between ε4 carriers and non-carriers, thus highlighting how genetic factors modulate the translation of the AD-related pathophysiological cascade into cognitive deficits.